Isozymes of lactate dehydrogenase. (A) The rat heart lactate dehydrogenase (LDH) isozyme profile changes in the course of development. The H isozyme is represented by squares and the M isozyme by circles. The negative and positive numbers denote the days before and after birth, respectively. (B) LDH isozyme content varies by tissue.

[(A) Data from W.-H. Li, Molecular Evolution (Sinauer, 1997), p. 283; (B) after K. Urich, Comparative Animal Biochemistry (Springer Verlag, 1990), p. 542.]