Amino acid residue | Transfer free energy in kJ mol−1 (kcal mol−1) |
|---|---|
Phe | 15.5 (3.7) |
Met | 14.3 (3.4) |
Ile | 13.0 (3.1) |
Leu | 11.8 (2.8) |
Val | 10.9 (2.6) |
Cys | 8.4 (2.0) |
Trp | 8.0 (1.9) |
Ala | 6.7 (1.6) |
Thr | 5.0 (1.2) |
Gly | 4.2 (1.0) |
Ser | 2.5 (0.6) |
Pro | −0.8 (−0.2) |
Tyr | −2.9 (−0.7) |
His | −12.6 (−3.0) |
Gln | −17.2 (−4.1) |
Asn | −20.2 (−4.8) |
Glu | −34.4 (−8.2) |
Lys | −37.0 (−8.8) |
Asp | −38.6 (−9.2) |
Arg | −51.7 (−12.3) |
Source: Data from D. M. Engelman, T. A. Steitz, and A. Goldman. Annu. Rev. Biophys. Biophys. Chem. 15(1986):32 | |
Note: The free energies are for the transfer of an amino acid residue in an α helix from the membrane interior (assumed to have a dielectric constant of 2) to water. | |