Pathway of gluconeogenesis. The reactions and enzymes unique to gluconeogenesis are shown in red. The other reactions are common to glycolysis. The enzymes for gluconeogenesis are located in the cytoplasm, except for pyruvate carboxylase (in the mitochondria) and glucose 6-phosphatase (membrane bound in the endoplasmic reticulum). The entry points for lactate, glycerol, and amino acids are shown.