Enzyme | Abbreviation | Number of chains | Prosthetic group | Reaction catalyzed |
|---|---|---|---|---|
Pyruvate dehydrogenase component | E1 | 24 | TPP | Oxidative decarboxylation of pyruvate |
Dihydrolipoyl transacetylase | E2 | 24 | Lipoamide | Transfer of acetyl group to CoA |
Dihydrolipoyl dehydrogenase | E3 | 12 | FAD | Regeneration of the oxidized form of lipoamide |