Structure of two nuclear hormone-receptor domains. Nuclear hormone receptors contain two crucial conserved domains: (1) a DNA-binding domain toward the center of the sequence and (2) a ligand-binding domain toward the carboxyl terminus. The structure of a dimer of the DNA-binding domain bound to DNA is shown, as is one monomer of the normally dimeric ligand-binding domain.

[Drawn from 1HCQ and 1LBD.pdb.]