Myosin conformational changes. A comparison of the overall structures of the myosin ATPase domain with ATP bound (shown in red) and that with the transition-state analog ADP–vanadate (shown in blue). Notice the large conformational change of a region at the carboxyl-terminus of the domain, some parts of which move as much as 25 Å.

[Drawn from 1FMW.pdb and 1VOM.pdb].