KEY TERMS

heme

protoporphyrin

proximal histidine

functional magnetic resonance imaging (fMRI)

superoxide anion

metmyoglobin

distal histidine

α chain

β chain

globin fold

oxygen-binding curve

fractional saturation

partial pressure

sigmoid

cooperative binding

T state

R state

concerted model (MWC model)

sequential model

2,3-bisphosphoglycerate

fetal hemoglobin

carbon monoxide

carboxyhemoglobin

Bohr effect

carbonic anhydrase

carbamate

sickle-cell anemia

hemoglobin S

sickle-cell trait

malaria

thalassemia

hemoglobin H

thalassemia major (Cooley anemia)

α-hemoglobin stabilizing protein (AHSP)

neuroglobin

cytoglobin

Hill plot

Hill coefficient