Where to Start

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Patel, K. P., O’Brien, T. W., Subramony, S. H., Shuster, J., and Stacpoole, P. W. 2012. The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients. Mol. Genet. Metab. 105:34–43.

Vijayakrishnan, S., Callow, P., Nutley, M. A., Mcgow, D. P., Gilbert, D., Kropholler, P., Cooper, A., Byron, O., and Lindsay, J. G. 2011. Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly. Biochem. J. 437:565–574.

Vijayakrishnan, S., Kelly, S. M., Gilbert, R. J., Callow, P., Bhella, D., Forsyth, T., Lindsay, J. G., and Byron, O. 2010. Solution structure and characterization of the human pyruvate dehydrogenase complex core assembly. J. Mol. Biol. 399:71–93.

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Hiromasa, Y., Fujisawa, T., Aso, Y., and Roche, T. E. 2004. Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding proteins and their capacities to bind the E1 and E3 components. J. Biol Chem. 279:6921–6933.

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B18

Fraser, M. E., Hayakawa, K., Hume, M. S., Ryan, D. G., and Brownie, E. R. 2006. Interactions of GTP with the ATP-grasp domain of GTP-specific succinyl-CoA synthetase. J. Biol. Chem. 281:11058–11065.

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Hiromasa, Y., and Roche, T. E. 2003. Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferases. J. Biol. Chem. 278:33681–33693.

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