Where to Start
Guarente, L. 2008. Mitochondria: A nexus for aging, calorie restriction, and sirtuins? Cell 132:171–
Wallace, D. C. 2007. Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine. Annu. Rev. Biochem. 76:781–
Hosler, J. P., Ferguson-
Gray, M. W., Burger, G., and Lang, B. F. 1999. Mitochondrial evolution. Science 283:1476–
Shultz, B. E., and Chan, S. I. 2001. Structures and proton-
Scheffler, I. E. 2007. Mitochondria. Wiley.
Lane, N. 2005. Power, Sex, Suicide: Mitochondria and the Meaning of Life. Oxford.
Nicholls, D. G., and Ferguson, S. J. 2013. Bioenergetics (4th ed.). Academic Press.
B19
Baradaran, R., Berrisford, J. M., Minhas, G. S., and Sazanov, L. A. 2013. Crystal structure of the entire respiratory complex I. Nature 494:443–
Lapuente-
Cammack, R. 2012. Iron-
Yoshikawa, S., Muramoto, K., and Shinzawa-
Qin, L., Liu, J., Mills, D. A., Proshlyakov, D. A., Hiser, C., and Ferguson-
Lill, R. 2009. Function and biogenesis of iron–
Cooley, C. W., Lee, D.-W., and Daldal, F. 2009. Across membrane communication between the Qo and Qi active sites of cytochrome bc1. Biochemistry 48:1888–
Verkhovskaya, M. L., Belevich, N., Euro, L., Wikström, M., and. Verkhovsky, M. I. 2008. Real-
Acín-
Kruse, S. E., Watt, W. C., Marcinek, D. J., Kapur, R. P., Schenkman, K. A., and Palmiter, R. D. 2008. Mice with mitochondrial Complex I deficiency develop a fatal encephalomyopathy. Cell Metab. 7:312–
Sun, F., Huo, X., Zhai, Y., Wang, A., Xu, J., Su, D., Bartlam, M., and Ral, Z. 2005. Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 121:1043–
Crofts, A. R. 2004. The cytochrome bc1 complex: Function in the context of structure. Annu. Rev. Physiol. 66:689–
Bianchi, C., Genova, M. L., Castelli, G. P., and Lenaz, G. 2004. The mitochondrial respiratory chain is partially organized in a supramolecular complex. J. Biol. Chem. 279:36562–
Cecchini, G. 2003. Function and structure of Complex II of the respiratory chain. Annu. Rev. Biochem. 72:77–
Lange, C., and Hunte, C. 2002. Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c. Proc. Natl. Acad. Sci. U.S.A. 99:2800–
Toei, M., and Noji, H. 2013. Single-
Watt, I. N., Montgomery, M. G., Runswick, M. J., Leslie, A. G. W., and Walker, J. E. 2010. Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria. Proc. Natl. Acad. Sci. U.S.A. 107:16823–
Wittig, I., and Hermann, S. 2009. Supramolecular organization of ATP synthase and respiratory chain in mitochondrial membranes. Biochim. Biophys. Acta 1787:672–
Junge, W., Sielaff, H., and Engelbrecht S. 2009. Torque generation and elastic power transmission in the rotary F0F1-ATPase. Nature 459:364–
von Ballmoos, C., Cook, G. M., and Dimroth, P. 2008. Unique rotary ATP synthase and its biological diversity. Annu. Rev. Biophys. 37:43–
Adachi, K., Oiwa, K., Nishizaka, T., Furuike, S., Noji, H., Itoh, H., Yoshida, M., and Kinosita, K., Jr. 2007. Coupling of rotation and catalysis in F1-ATPase revealed by single-
Chen, C., Ko, Y., Delannoy, M., Ludtke, S. J., Chiu, W., and Pedersen, P. L. 2004. Mitochondrial ATP synthasome: Three-
Noji, H., and Yoshida, M. 2001. The rotary machine in the cell: ATP synthase. J. Biol. Chem. 276:1665–
Yasuda, R., Noji, H., Kinosita, K., Jr., and Yoshida, M. 1998. F1-ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps. Cell 93:1117–
Noji, H., Yasuda, R., Yoshida, M., and Kinosita, K., Jr., 1997. Direct observation of the rotation of F1-ATPase. Nature 386:299–
Tsunoda, S. P., Aggeler, R., Yoshida, M., and Capaldi, R. A. 2001. Rotation of the c subunit oligomer in fully functional F1 F0 ATP synthase. Proc. Natl. Acad. Sci. U.S.A. 987:898–
Gibbons, C., Montgomery, M. G., Leslie, A. G. W., and Walker, J. 2000. The structure of the central stalk in F1-ATPase at 2.4 Å resolution. Nat. Struct. Biol. 7:1055–
Sambongi, Y., Iko, Y., Tanabe, M., Omote, H., Iwamoto-
Villarroya, F., and Vidal-
Rey, M., Forest, E., and Pelosi, L. 2012. Exploring the conformational dynamics of the bovine ADP/ATP carrier in mitochondria. Biochemistry 51:9727–
Divakaruni, A. S., Humphrey, D. M., and Brand, M. D. 2012. Fatty acids change the conformation of uncoupling protein 1 (UCP1). J. Biol. Chem. 44:36845–
Fedorenko, A., Lishko, P. V., and Kirichok, Y. 2012. Mechanism of fatty-
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., and Teule, G. J. 2009. Cold-
Cypess, A. M., Sanaz Lehman, S., Gethin Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. 2009. Identification and importance of brown adipose tissue in adult humans. New Engl. J. Med. 360:1509–
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. 2009. Functional brown adipose tissue in healthy adults. New Engl. J. Med. 360:1518–
Bayrhuber, M., Meins, T., Habeck, M., Becker, S., Giller, K., Villinger, S., Vonrhein, C., Griesinger, C., Zweckstetter, M., and Zeth, K. 2008. Structure of the human voltage-
Bamber, L., Harding, M., Monné, M., Slotboom, D.-J., and Kunji, E. R. 2007. The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes. Proc. Natl. Acad. Sci. U.S.A. 10:10830–
Pebay-
Sena, L. A., and Chandel, N. S. 2012. Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 48:158–
Forman, H. J., Maiorino, M., and Ursini, F. 2010. Signaling functions of reactive oxygen species. Biochemistry 49:835–
Murphy, M. P. 2009. How mitochondria produce reactive oxygen species. Biochem. J. 417:1–
B20
Leitch, J. M., Yick, P. J., and Culotta, V. V. 2009. The right to choose: Multiple pathways for activating copper, zinc superoxide dismutase. J. Biol. Chem. 284:24679–
Winterbourn, C. C. 2008. Reconciling the chemistry and biology of reactive oxygen species. Nat. Chem. Biol. 4:278–
Veal, E. A., Day, A. M., and Morgan, B. A. 2007. Hydrogen peroxide sensing and signaling. Mol. Cell 26:1–
Stone, J. R., and Yang, S. 2006. Hydrogen peroxide: A signaling messenger. Antioxid. Redox Signal. 8:243–
Valentine, J. S., Doucette, P. A., and Potter S. Z. 2005. Copper-
Papa, S., and De Rasmo, D. 2013. Complex I deficiencies in neurological disorders. Trends Mol. Med. 19:61–
Koopman, W. J. H., Willems, P. H. G. M., and Smeitink, J. A. M. 2012. Monogenic mitochondrial disorders. New Engl. J. Med. 366:1132–
Lina, C. S., Sharpley, M. S., Fan W., Waymire, K. G., Sadun, A. A., Carelli, V., Ross-
Mitochondria Disease. 2009. A compendium of nine articles on mitochondrial diseases. Biochem. Biophys. Acta Mol. Basis Disease 1792:1095–
Cicchetti, F., Drouin-
DiMauro, S., and Schon, E. A. 2003. Mitochondrial respiratory-
Smeitink, J., van den Heuvel, L., and DiMauro, S. 2001. The genetics and pathology of oxidative phosphorylation. Nat. Rev. Genet. 2:342–
Qi, S., Pang, Y., Hu, Q., Liu, Q., Li, H., Zhou, Y., He, T., Liang, Q., Liu, Y., Yuan, X., et al. 2010. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-
Chan, D. C. 2006. Mitochondria: Dynamic organelles in disease, aging, and development. Cell 125:1241–
Green, D. R. 2005. Apoptotic pathways: Ten minutes to dead. Cell 121:671–
Prebble, J., and Weber, B. 2003. Wandering in the Gardens of the Mind: Peter Mitchell and the Making of Glynn. Oxford.
Mitchell, P. 1979. Keilin’s respiratory chain concept and its chemiosmotic consequences. Science 206:1148–
Preeble, J. 2002. Peter Mitchell and the ox phos wars. Trends Biochem. Sci. 27:209–
Mitchell, P. 1976. Vectorial chemistry and the molecular mechanics of chemiosmotic coupling: Power transmission by proticity. Biochem. Soc. Trans. 4:399–
Racker, E. 1980. From Pasteur to Mitchell: A hundred years of bioenergetics. Fed. Proc. 39:210–
Kalckar, H. M. 1991. Fifty years of biological research: From oxidative phosphorylation to energy requiring transport and regulation. Annu. Rev. Biochem. 60:1–