Chapter 4

Where to Start

Felsenfeld, G. 1985. DNA. Sci. Am. 253(4):58–67.

Darnell, J. E., Jr. 1985. RNA. Sci. Am. 253(4):68–78.

Dickerson, R. E. 1983. The DNA helix and how it is read. Sci. Am. 249(6):94–111.

Crick, F. H. C. 1954. The structure of the hereditary material. Sci. Am. 191(4):54–61.

Chambon, P. 1981. Split genes. Sci. Am. 244(5):60–71.

Watson, J. D., and Crick, F. H. C. 1953. Molecular structure of nucleic acids: A structure for deoxyribose nucleic acid. Nature 171:737–738.

Watson, J. D., and Crick, F. H. C. 1953. Genetic implications of the structure of deoxyribonucleic acid. Nature 171:964–967.

Meselson, M., and Stahl, F. W. 1958. The replication of DNA in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 44:671–682.

Books

Bloomfield, V. A., Crothers, D. M., Tinoco, I., and Hearst, J. 2000. Nucleic Acids: Structures, Properties, and Functions. University Science Books.

Singer, M., and Berg, P. 1991. Genes and Genomes: A Changing Perspective. University Science Books.

B3

Lodish, H., Berk, A., Kaiser, C. A., Krieger, M. Bretscher, A., Ploegh, H., Amon, A., and Scott, M. P. 2012. Molecular Cell Biology (7th ed.). W. H. Freeman and Company.

Krebs, J. E, Goldstein, E. S. and Kilpatrick, S. T. 2012. Lewin’s Genes XI. (11th ed.). Jones and Bartlett.

Watson, J. D., Baker, T. A., Bell, S. P., Gann, A., Levine, M., and Losick, R. 2013. Molecular Biology of the Gene (7th ed.). Benjamin Cummings.

DNA Structure

Neidle, S. 2007. Principles of Nucleic Acid Structure. Academic Press.

Dickerson, R. E., Drew, H. R., Conner, B. N., Wing, R. M., Fratini, A. V., and Kopka, M. L. 1982. The anatomy of A-, B-, and Z-DNA. Science 216:475–485.

Sinden, R. R. 1994. DNA Structure and Function. Academic Press.

DNA Replication

Lehman, I. R. 2003. Discovery of DNA polymerase. J. Biol. Chem. 278:34733–34738.

Hübscher, U., Maga, G., and Spardari, S. 2002. Eukaryotic DNA polymerases. Annu. Rev. Biochem. 71:133–163.

Hübscher, U., Nasheuer, H.-P., and Syväoja, J. E. 2000. Eukaryotic DNA polymerases: A growing family. Trends Biochem. Sci. 25:143–147.

Brautigam, C. A., and Steitz, T. A. 1998. Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Curr. Opin. Struct. Biol. 8:54–63.

Kornberg, A. 2005. DNA Replication (2d ed.). University Science Books.

Discovery of Messenger RNA

Jacob, F., and Monod, J. 1961. Genetic regulatory mechanisms in the synthesis of proteins. J. Mol. Biol. 3:318–356.

Brenner, S., Jacob, F., and Meselson, M. 1961. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature 190:576–581.

Hall, B. D., and Spiegelman, S. 1961. Sequence complementarity of T2-DNA and T2-specific RNA. Proc. Natl. Acad. Sci. U.S.A. 47:137–146.

Genetic Code

Novoa, E. M., and Ribas de Pouplana, L. 2012. Speeding with control: Codon usage, tRNAs, and ribosomes. Trends Genet. 28:574–581.

Koonin, E. V., and Novozhilov, A. S. 2009. Origin and evolution of the genetic code: The universal enigma. IUBMB Life 61:99–111.

Yarus, M., Caporaso, J. G., and Knight, R. 2005. Origins of the genetic code: The escaped triplet theory. Annu. Rev. Biochem. 74:179–198.

Freeland, S. J., and Hurst, L. D. 2004. Evolution encoded. Sci. Am. 290(4):84–91.

Crick, F. H. C., Barnett, L., Brenner, S., and Watts-Tobin, R. J. 1961. General nature of the genetic code for proteins. Nature 192:1227–1232.

Knight, R. D., Freeland, S. J., and Landweber L. F. 1999. Selection, history and chemistry: The three faces of the genetic code. Trends Biochem. Sci. 24(6):241–247.

Introns, Exons, and Split Genes

Liu, M., and Grigoriev, A. 2004. Protein domains correlate strongly with exons in multiple eukaryotic genomes—evidence of exon shuffling? Trends Genet. 20:399–403.

Dorit, R. L., Schoenbach, L., and Gilbert, W. 1990. How big is the universe of exons? Science 250:1377–1382.

Cochet, M., Gannon, F., Hen, R., Maroteaux, L., Perrin, F., and Chambon, P. 1979. Organization and sequence studies of the 17-piece chicken conalbumin gene. Nature 282:567–574.

Tilghman, S. M., Tiemeier, D. C., Seidman, J. G., Peterlin, B. M., Sullivan, M., Maizel, J. V., and Leder, P. 1978. Intervening sequence of DNA identified in the structural portion of a mouse β-globin gene. Proc. Natl. Acad. Sci. U.S.A. 75:725–729.

Reminiscences and Historical Accounts

Watson, J. D., Gann, A., and Witkowski, J. (Eds.). 2012. The Annotated and Illustrated Double Helix. Simon and Shuster.

Nirenberg, M. 2004. Deciphering the genetic code—a personal account. Trends Biochem. Sci. 29:46–54.

Clayton, J., and Dennis, C. (Eds.). 2003. 50 Years of DNA. Palgrave Macmillan.

Watson, J. D. 1968. The Double Helix. Atheneum.

McCarty, M. 1985. The Transforming Principle: Discovering That Genes Are Made of DNA. Norton.

Cairns, J., Stent, G. S., and Watson, J. D. 2000. Phage and the Origins of Molecular Biology. Cold Spring Harbor Laboratory.

Olby, R. 1974. The Path to the Double Helix. University of Washington Press.

Judson, H. F. 1996. The Eighth Day of Creation. Cold Spring Harbor Laboratory.

Sayre, A. 2000. Rosalind Franklin and DNA. Norton.