KEY TERMS

pyrimidine nucleotide

carbamoyl phosphate synthetase II (CPS II)

ATP-grasp fold

5-phosphoribosyl-1-pyrophosphate (PRPP)

orotidylate

salvage pathway

purine nucleotide

glutamine phosphoribosyl amidotransferase

ribonucleotide reductase

thymidylate synthase

dihydrofolate reductase

severe combined immunodeficiency (SCID)

gout

Lesch–Nyhan syndrome

spina bifida

neural-tube defect

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