KEY TERMS

innate immune system

adaptive immune system

phagocyte

Toll-like receptor (TLR)

pathogen-associated molecular pattern (PAMP)

endotoxin

humoral immune response

B lymphocyte (B cell)

1009

antigen

antigenic determinant (epitope)

cellular immune response

cytotoxic T lymphocyte (killer T cell)

helper T lymphocyte (helper T cell)

immunoglobulin G (IgG)

Fab

Fc

light (L) chain

heavy (H) chain

segmental flexibility

immunoglobulin M (IgM)

immunoglobulin A (IgA)

immunoglobulin D (IgD)

immunoglobulin E (IgE)

variable region

constant region

immunoglobulin fold

hypervariable loop

complementarity-determining region (CDR)

V(D)J recombination

immunoreceptor tyrosine-based activation motif (ITAM)

cyclosporine

hapten

class switching

major histocompatibility complex (MHC)

class I MHC protein

TAP (transporter associated with antigen processing) protein

human leukocyte antigen (HLA)

β2-microglobulin

T-cell receptor

CD8

perforin

granzyme

class II MHC protein

CD4

plasma cell

human immunodeficiency virus (HIV)

positive selection

negative selection

autoimmune disease

carcinoembryonic antigen (CEA)

vaccine

immunological memory

killed, or inactivated, vaccines

live attenuated vaccines

subunit vaccines

toxoid vaccines