Chapter 36. Chapter 36
Introduction
Problem-Solving Video Assessment
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Chapter 36 Problem-Solving Video Assessment
The drug favipiravir has shown promise as an antiviral therapy in mouse models of Ebola virus infection. Researchers believe it works by inhibiting the RNA-dependent RNA polymerase of Ebola. You would like to test this hypothesis by directly measuring how well favipiravir inhibits this polymerase in vitro. To do so, you measure RNA polymerase activity with the nucleotide substrate present at a concentration equal to twice its KM value. The results of the assay are below:
| Favipiravir (μm) | Units of RNA polymerase activity |
|---|---|
| 0 | 80.4 |
| 0.5 | 72.5 |
| 1 | 65.6 |
| 1.5 | 61.8 |
| 2 | 53.3 |
| 5 | 47.9 |
| 10 | 40.2 |
| 25 | 21.1 |
| 50 | 11.2 |
| 100 | 8.4 |
Table
Question 36.1
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_feedback_correct: Correct.
_feedback_incorrect: Incorrect.
Question 36.2
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_feedback_correct: Correct.
_feedback_incorrect: Incorrect.
Question 36.3
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_feedback_correct: Correct.
_feedback_incorrect: Incorrect.
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