American attitudes toward cigarettes, drugs, and alcohol have shifted over time. There was a period when the U.S. government outlawed the production and sale of alcohol, but Prohibition (1920–1933) inadvertently triggered massive bootlegging. The people would have their booze. There was a time when opiates were the gentleman’s drug of choice. There was also a time when cigarette ads featured medical doctors who assured consumers of the safety, quality, and benefits of smoking; consumers had yet to learn about the addictiveness of nicotine or the hazards of lung cancer. In this cluster, a spoof ad and a portfolio of vintage cigarette ads highlight the changes in our thinking about smoking. Two more pieces focus on addiction: an annotated map points out America’s alarming dependence on drugs and alcohol, and a companion chart gives facts about the impact of these substances on the human body.