WEBVTT 1 00:00:06.800 --> 00:00:13.000 Heroin and Morphine are common versions of drugs known as opiates. 2 00:00:13.000 --> 00:00:16.500 They are better known as narcotics. 3 00:00:16.500 --> 00:00:23.000 These drugs are based on opium which is an extract from the opium poppy. 4 00:00:23.000 --> 00:00:31.000 These drugs are highly addictive, and this addiction has been a serious health problem for centuries. 5 00:00:31.000 --> 00:00:41.000 Morphine is used medically as a pain reliever though heroin is only used recreationally. 6 00:00:45.000 --> 00:00:54.900 The story of the discovery of how heroin, morphine and other opiates work is a fascinating story 7 00:00:54.900 --> 00:01:02.000 and leads to the discovery of a new class of neurotransmitters, sometimes called endorphins 8 00:01:02.000 --> 00:01:10.000 It turns out that all opiates act to mimic these natural neurotransmitters. 9 00:01:10.000 --> 00:01:18.000 Opiates bind to the to the endorphin receptors and have the same effect on the post-synaptic neuron. 10 00:01:18.000 --> 00:01:23.000 The effects are found both in the central and peripheral nervous system 11 00:01:23.000 --> 00:01:32.000 but two regions are very important, the ventral tegmental area and nucleus accumbens. 12 00:01:32.000 --> 00:01:45.000 Both the ventral tegmental area and nucleus accumbens are important parts of the brains natural reward circuitry.