WEBVTT 1 00:00:06.000 --> 00:00:10.000 Many people experience severe depression. 2 00:00:10.000 --> 00:00:18.000 One part of the treatment of depression is to give antidepressants, which work for many people. 3 00:00:23.000 --> 00:00:36.000 Antidepressant drugs work to keep the neurotransmitters serotonin and norepinephrine around in the synapse for a much longer time. 4 00:00:36.000 --> 00:00:43.000 They do not allow these neurotransmitters to reenter the presynaptic neuron. 5 00:00:58.000 --> 00:01:08.000 The cells that produce these neurotransmitters start in the brain stem and travel widely through the forebrain and limbic system.