WEBVTT 1 00:00:06.000 --> 00:00:12.500 In our second drug, it binds to the receptor but it does not open the channel 2 00:00:12.500 --> 00:00:20.000 and cause the postsynaptic neuron it is bound to to fire or respond in any way. 3 00:00:20.000 --> 00:00:28.000 When the neurotransmitter is released from the presynaptic neuron it cannot bind to the receptors.