WEBVTT 1 00:00:00.000 --> 00:00:05.000 In our third drug, it actually impacts the presynaptic neuron. 2 00:00:05.000 --> 00:00:15.500 In most neurons, when they release the neurotransmitter, they bind to the postsynaptic neuron, and then release from the receptor. 3 00:00:15.500 --> 00:00:24.000 In many kinds of neurons, the neurotransmitter is then taken back up by the presynaptic neuron. 4 00:00:24.300 --> 00:00:35.800 But when this drug is present, the neurons are not taken back up by the presynaptic neuron, they stay in the gap and may even bind again. 5 00:00:35.800 --> 00:00:39.000 The synapse becomes more active.