Chapter 3. Common Genetic Diseases and Conditions

3.1 Synopsis

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You must read each slide, and complete any questions on the slide, in sequence.

Welcome

Common Genetic Diseases
and Conditions

This activity examines several different types of genetic diseases and conditions.

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A young pregnant couple listen carefully to a lady doctor.

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3.2 Common Genetic Diseases and Conditions

Common Genetic Diseases and Conditions

Everyone carries alleles that could produce serious diseases or conditions in their offspring. Most such genes have no serious consequences because they are recessive. The phenotype is affected only when the inherited condition is dominant or when a zygote is homozygous for a particular recessive condition, that is, when the zygote has received the recessive gene from both parents.

Click on each condition to view its characteristics.

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3.3 Common Genetic Diseases and Conditions

Common Genetic Diseases and Conditions

A small girl with down's syndrome laughs.

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Question 3.1 Testing for genetic disorders during a pregnancy

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Your answer should address the incidence of the disease(s) you selected, the family history, ethnic background, and carrier status (if applicable) of the both of you, as well as whether the disorder can be detected prenatally.

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REFERENCES

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Butler, Merlin Gene, & Meaney, F. John. (2005). Genetics of developmental disabilities. Boca Raton, FL: Taylor & Francis.

Cruz-Inigo, Andres E., Ladizinski, Barry, & Sethi, Aisha. (2011). Albinism in Africa: Stigma, slaughter, and awareness campaigns. Dermatologic Clinics, 29, 79–87.

Haydon, Jo. (2007). Genetics in practice: A clinical approach for healthcare practitioners.Hoboken, NJ: Wiley.

Hemminki, Kari, Sundquist, Jan, & Lorenzo Bermejo, Justo. (2008). Familial risks for cancer as the basis for evidence-based clinical referral and counseling. The Oncologist,13, 239–247.

Klug, William, Cummings, Michael, Spencer, Charlotte, & Palladino, Michael. (2008). Concepts of genetics (9^th ed.). San Francisco, CA: Pearson/Benjamin Cummings.

McKusick, Victor A. (2007). Mendelian Inheritance in Man and its online version, OMIM.American Journal of Human Genetics, 80, 588–604.

Moore, Keith L., & Persaud, Trivedi V. N. (2007). The developing human: Clinically oriented embryology (8^th ed.). Philadelphia, PA: Saunders/Elsevier.

Shahin, Hashem, Walsh, Tom, Sobe, Tama, Lynch, Eric, King, Mary-Claire, Avraham, Karen, et al. (2002). Genetics of congenital deafness in the Palestinian population: Multiple conexin 26 alleles with shared origins in the Middle East. Human Genetics, 110, 284–289.