Chapter 1. DNA Question Suites

1.1 Rubric

Use 1A as a pre-class warm up question. Start the discussion in class with 1B. Ask 1C for discussion. If students choose B as a correct answer, ask them to list all proteins that bind RNA. If they pick C, use it as a lead-in question to ask why this is the case to talk about Chargaff’s rules and structure in general. Follow up with 1D.

To make 1C a fully stand-alone exam question, modify to ask What features of DNA make it a more suitable molecule than RNA? Adjust by asking, what 2 features, what 3 features?

1.2 Pre-class/warm up question 1A:

Question 1.1

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1.3 In-class warm up question 1B:

Draw a table comparing the structures and functions of DNA and RNA:

1.4 Questions 1C & 1D

You have been tasked with deciding how best to create, store, and process the genetic information within an artificial cell line. Your team would like to make the most efficient cell possible to keep costs to a minimum.

Question 1.2

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Question 1.3

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1.5 Base Pairing Rubric

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1.6 Warm Up Question 2A

Question 1.4

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1.7 2B

Question 1.5

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1.8 2C

Question 1.6

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1.9 In-Class Activity

2D. Show images of spiral staircases—the kind with the pole in the middle, and the other kind. Which is the better analogy for DNA’s double helix?

2E. How do you build a spiral staircase if you only have planks of two different lengths—one short and one long? How do you keep a constant distance between the two railings? What happens if you put together two short planks in a step, or two long planks? Applying this analogy to the structure of DNA and using what you know about bases, which plank do you think represents A? T? What does the railing represent? What sticks the boards together—how many types of glue do you need to use?