| 1809 | Non-Intercourse Act |
| 1811 | First steamboat travels down the Mississippi |
| William Henry Harrison defeats Shawnees at Prophet Town |
| June 1812 | War of 1812 begins |
| 1814 | Hartford Convention |
| March 1814 | Battle of Horseshoe Bend |
| August 1814 | British burn Washington City |
| December 1814 | Treaty of Ghent |
| 1815 | Battle of New Orleans |
| 1817–1818 | Andrew Jackson fights Spanish and Seminole forces in Florida |
| 1818 | Great Britain and United States agree to joint occupation of Oregon Territory |
| 1819 | Adams-Onís Treaty |
| 1819–1823 | Panic of 1819 |
| 1820 | Missouri Compromise |
| 1821 | White traders begin using Santa Fe Trail |
| 1822 | Denmark Vesey accused of organizing a slave uprising |
| 1823 | Monroe Doctrine articulated |
| 1825 | Erie Canal completed |
| 1828 | Tariff of 1828 (Tariff of Abominations) |
| John Ross elected principal chief of the Cherokee nation |
| 1829 | Petticoat Affair |
| 1830 | Indian Removal Act |
| 1832 | South Carolina passes Ordinance of Nullification |
| 1833 | Force Bill |