Chapter 1. Cell Signaling

1.1 Section Title

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Question

Arrange the events in the stimulation of heart muscle in order from earliest (1) to latest (5). Note that this question does not list every step in the pathway, but the steps presented should be arranged in order.

q/f8vhMT4Ss2VgB/yUKoCQ== Activation of adenylyl cyclase

teVQRmeRm40fzbD8fdZ0FA== Activation of G-proteins

ltpEFresVuq3mawql2LXqQ== Activation of protein kinase A

vYTlT+7nOshg2/gEWoORgg== Phosphorylation of proteins that induce contraction in muscle cells

Te4Nr4FpUtIeClDvB7syig== Conversion of ATP into cyclic AMP

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Incorrect. The correct order is: 1. Activation of G-proteins, 2. Activation of adenylyl cyclase, 3. Conversion of ATP into cyclic AMP, 4. Activation of protein kinase A, 5. Phosphorylation of proteins that induce contraction in muscle cells

Question

Which of the following could lead to a prolonged increase in heart rate, even in the absence of an external signal? Choose all that apply.

a. An inability of a G-protein to hydrolyze GTP wg8JNehuALfILP6S

b. An inability to inactivate protein kinase A wg8JNehuALfILP6S

c. An inability of G-protein coupled receptors to bind adrenaline 3hMJDRP6OS+3EJIb

d. An inability of cyclic AMP to activate protein kinase A 3hMJDRP6OS+3EJIb

e. An inability to convert ATP into cyclic AMP 3hMJDRP6OS+3EJIb

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