Table 16-1: Functions of Wild-Type Proteins and Properties of Tumor-Promoting Mutations in the Corresponding Genes

Wild-type protein function	Properties of tumor-promoting mutations
Promotes cell-cycle progression	Oncogene (gain of function)
Inhibits cell-cycle progression	Tumor-suppressor mutation (loss of function)
Promotes apoptosis	Tumor-suppressor mutation (loss of function)
Inhibits apoptosis	Oncogene (gain of function
Promotes DNA repair	Tumor-suppressor mutation (loss of function)