Inversions may cause a variety of structural changes in the DNAAn inversion may have no effect on genes, may disrupt a gene, or may fuse parts of two genes, depending on the location of the break point. Genes are represented by A, B, C, and D. Template strand is dark green; nontemplate strand is light green; jagged red lines indicate where breaks in the DNA produced gene fusions (A with D) after inversion and rejoining. The letter P stands for promoter; arrows indicate the positions of the break points.