Nucleotide variation at the G6PD gene in humans

Nucleotide variation for 5102 bp of the G6PD gene for a worldwide sample of 47 men. Only the 18 variable sites are shown. The functional allele class (A⁻, A⁺, or β) is shown for each sequence. SNP2 is a nonsynonymous SNP that causes a valine-to-methionine change that underlies differences in enzyme activity associated with the A⁻ allele. SNP3 is a nonsynonymous SNP that causes an aspartic-acid-to-asparagine amino acid change.

[Data from M. A. Saunders et al., Genetics 162, 2002, 1849-1861]