Protein and RNA molecules compose the two subunits of a ribosomeA ribosome contains a large and a small subunit. Each subunit contains both rRNA of varying lengths and a set of proteins. There are two principal rRNA molecules in all ribosomes. Prokaryotic ribosomes also contain one 120-base-long rRNA that sediments at 5S, whereas eukaryotic ribosomes have two small rRNAs: a 5S RNA molecule similar to the prokaryotic 5S and a 5.8S molecule 160 bases long.