Preface

xiii

  1

  The Genetics Revolution

1

 PART I  TRANSMISSION GENETICS

  2

  Single-Gene Inheritance

31

  3

  Independent Assortment of Genes

87

  4

  Mapping Eukaryote Chromosomes by Recombination

127

  5

  The Genetics of Bacteria and Their Viruses

173

  6

  Gene Interaction

215

 PART II  FROM DNA TO PHENOTYPE

  7

  DNA: Structure and Replication

259

  8

  RNA: Transcription and Processing

291

  9

  Proteins and Their Synthesis

319

10

  Gene Isolation and Manipulation

351

11

  Regulation of Gene Expression in Bacteria and Their Viruses

397

12

  Regulation of Gene Expression in Eukaryotes

431

13

  The Genetic Control of Development

469

14

  Genomes and Genomics

507

 PART III  MUTATION, VARIATION, AND EVOLUTION

15

  The Dynamic Genome: Transposable Elements

547

16

  Mutation, Repair, and Recombination

581

17

  Large-Scale Chromosomal Changes

617

18

  Population Genetics

665

19

  The Inheritance of Complex Traits

715

20

  Evolution of Genes and Traits

761

A Brief Guide to Model Organisms

759

Appendix A: Genetic Nomenclature

775

Appendix B: Bioinformatics Resources for Genetics and Genomics

776

Glossary

779

Answers to Selected Problems

797

Index

809