EXAMPLE 1.21

Healthy bones and PTH. Bones are constantly being built up (bone formation) and torn down (bone resorption). Young people who are growing have more formation than resorption. When we age, resorption increases to the point where it exceeds formation. (The same phenomenon occurs when astronauts travel in space.) The result is osteoporosis, a disease associated with fragile bones that are more likely to break. The underlying mechanisms that control these processes are complex and involve a variety of substances. One of these is parathyroid hormone (PTH). Here are the values of PTH measured on a sample of 29 boys and girls aged 12 to 15 years:7

39 59 30 48 71 31 25 31 71 50 38 63 49 45 31
33 28 40 127 49 59 50 64 28 46 35 28 19 29
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Figure 1.11 Stemplot of the values of PTH, Example 1.21.

The data are measured in picograms per milliliter (pg/ml) of blood. The original data were recorded with one digit after the decimal point. They have been rounded to simplify our presentation here. Figure 1.11 gives a stemplot of the data.

The observation 127 clearly stands out from the rest of the distribution. A PTH measurement on this individual taken on a different day was similar to the rest of the values in the data set. We conclude that this outlier was caused by a laboratory error or a recording error, and we are confident in discarding it for any additional analysis.