EXAMPLE 1.22

Seasonal variation in vitamin D. Although we get some of our vitamin D from food, most of us get about 75% of what we need from the sun. Cells in the skin make vitamin D in response to sunlight. If people do not get enough exposure to the sun, they can become deficient in vitamin D, resulting in weakened bones and other health problems. The elderly, who need more vitamin D than younger people, and people who live in northern areas, where there is relatively little sunlight in the winter, are particularly vulnerable to these problems.

Figure 1.12 is a plot of the serum levels of vitamin D versus time of year for samples of subjects from Switzerland.⁸ The units measuring Vitamin D are nanomoles per liter (nmol/l) of blood. The observations are grouped into periods of two months for the plot. Means are marked by filled-in circles and are connected by a line in the plot. The effect of the lack of sunlight in the winter months on vitamin D levels is clearly evident in the plot.