EXAMPLE 3.34

The Tuskegee study. In the 1930s, syphilis was common among black men in the rural South, a group that had almost no access to medical care. The Public Health Service Tuskegee study recruited 399 poor black sharecroppers with syphilis and 201 others without the disease in order to observe how syphilis progressed when no treatment was given. Beginning in 1943, penicillin became available to treat syphilis. The study subjects were not treated. In fact, the Public Health Service prevented any treatment until word leaked out and forced an end to the study in the 1970s.

The Tuskegee study is an extreme example of investigators following their own interests and ignoring the well-being of their subjects. A 1996 review said, “It has come to symbolize racism in medicine, ethical misconduct in human research, paternalism by physicians, and government abuse of vulnerable people.” In 1997, President Clinton formally apologized to the surviving participants in a White House ceremony.²⁶