FIGURE 12-30 Craving Increases OMPFC Network Coupling Participants craving nicotine show an increase in the coupling of the orbital and medial prefrontal cortex (OMPFC, shown in green) with other regions including anterior cingulate cortex, other prefrontal regions, the striatum, right hippocampal region, ventral occipital cortex, and cerebellum (shown in shades of orange).

An Increase in Tobacco Craving Is Associated with Enhanced Medial Prefrontal Cortex Network Coupling Amy C. Janes, Stacey Farmer, Blaise deB. Frederick, Lisa D. Nickerson, Scott E. Lukas, PLoS One. 2014 Feb 5;9(2):e88228. doi: 10.1371/journal.pone.0088228.eCollection 2014.