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Figure 14.18 Testing the Signal

Original Paper: Dingwall, C. et al. 1988. The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen. Journal of Cell Biology 107: 841–849.

A. Richardson and his colleagues performed a series of experiments to test whether the nuclear localization signal (NLS) is all that is needed to direct a protein to the nucleus.