Figure 43.10 The Dorsal Lip Induces Embryonic Organization

Original Paper: Spemann, H. and H. Mangold. 1924. Roux’ Arch. Entw. Mech. 100: 599–638. Viktor Hamburger’s translation appeared in Foundations of Experimental Embryology, 1964, (B. H. Willier and J. M. Oppenheimer, eds.), pp. 146–184.

In a classic experiment, Hans Spemann and Hilde Mangold transplanted the dorsal blastopore lip mesoderm of an early gastrula stage salamander embryo. The results showed that the cells of this embryonic region, which they dubbed “the organizer,” could direct the formation of an entire embryo.