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Figure 51.11 The Kidney Excretes Acids and Conserves Bases (A) Bicarbonate ions are filtered out of the blood at the glomerulus, and renal tubule cells secrete hydrogen ions into the tubule fluid. In the renal tubule, the filtered bicarbonate buffers the secreted hydrogen ions and keeps the urine from becoming too acidic. The CO2 formed by the reaction of bicarbonate and hydrogen ions is converted back to bicarbonate by the renal tubule cells and transported back into the interstitial fluid. (B) Excretion of ammonium ions (NH4+) by renal tubule cells is also important for acid–base balance.