Prokaryotes | Eukaryotes | |
---|---|---|
Locations of functionally related genes | Often clustered in operons | Often distant from one another with separate promoters |
RNA polymerases | One | Three: |
| ||
Promoters and other regulatory sequences | Few | Many |
Initiation of transcription | Binding of RNA polymerase to promoter | Binding of many proteins, including RNA polymerase |