Microsporidia are highly reduced, parasitic fungi

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Microsporidia are unicellular parasitic fungi. They are among the smallest eukaryotes known, with infective spores that are only 1–40 micrometers (µm) in diameter. About 1,500 species have been described, but many more species are thought to exist. Their relationships among the eukaryotes have puzzled biologists for many decades

Microsporidia lack true mitochondria, although they have reduced structures, known as mitosomes, that are derived from mitochondria. Unlike mitochondria, however, mitosomes contain no DNA—the mitochondrial genome has been completely transferred to the nucleus. Because microsporidia lack mitochondria, biologists initially suspected that they represented an early lineage of eukaryotes that diverged before the endosymbiotic event from which mitochondria evolved. The presence of mitosomes, however, indicates that this hypothesis is incorrect. DNA sequence analysis, along with the fact that their cell walls contain chitin, has confirmed that the microsporidia are in fact highly reduced, parasitic fungi, although their exact placement among the fungal lineages is still being investigated.

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Microsporidia are obligate intracellular parasites of animals, especially of insects, crustaceans, and fish. Some species are known to infect mammals, including humans. Most infections by microsporidia cause chronic disease in the host, with effects that include weight loss, reduced fertility, and a shortened life span. The host cell is penetrated by a polar tube that grows from the microsporidian spore. The function of the polar tube is to inject the contents of the spore, the sporoplasm, into the host (Figure 29.13). The sporoplasm then replicates within the host cell and produces new infective spores. The life cycle of some species is complex and involves multiple hosts, whereas other species infect a single host. In some insects, parasitic microsporidia are transmitted vertically (i.e., from parent to offspring). Reproduction is thought to be strictly asexual in some microsporidians, but includes poorly understood asexual and sexual cycles in other species.

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Figure 29.13 Invasion of the Microsporidia The spores of microsporidia grow polar tubes that transfer the contents of the spores into the host’s cells. The species shown here infects many animals, including humans.