Food provides carbon skeletons for biosynthesis

Every animal must take in certain organic molecules that it cannot synthesize for itself but needs to form the building blocks of its own complex organic molecules. The acetyl group (CH3CO—) is one such required building block, supplying the carbon skeleton of larger organic molecules (Figure 50.4). Animals cannot synthesize acetyl groups from carbon, oxygen, and hydrogen molecules but must obtain them from food. Acetyl groups can be derived from the metabolism of almost any food, but they originate in plants.

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Figure 50.4 The Acetyl Group Is an Acquired Carbon Skeleton Animals cannot synthesize the acetyl group for themselves, but they ingest it in their food and use it to synthesize a wide variety of molecules.

Acetyl groups are never in short supply for an adequately nourished animal. However, some groups supplying carbon skeletons can be deficient in an animal’s diet even if caloric intake is adequate. One such group includes certain amino acids, the building blocks of proteins. Animals can synthesize some of their own amino acids using carbon skeletons from acetyl or other groups and transferring to them amine groups (—NH2) derived from other amino acids. However, most animals cannot synthesize all the amino acids they need and thus must obtain certain essential amino acids from food. If an animal does not take in enough of even one of its essential amino acids, its protein synthesis is impaired and its capacity to maintain enzymatic and transport functions is challenged.

Essential amino acids vary by species. Most researchers agree that adult humans must obtain eight essential amino acids from their food: isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. All eight are available in milk, eggs, meat, and soybean products, but most plant foods do not contain adequate quantities of all eight, so a strict vegetarian diet carries a risk of protein malnutrition. A complementary diet of plant foods, however, supplies all eight essential amino acids (Figure 50.5). In general, grains (such as rice, wheat, and corn) are complemented by legumes (such as beans and peas). Long before the chemical basis for complementarity was understood, societies with little access to meat developed complementary diets. Many Central and South American peoples traditionally eat beans with corn, and the native peoples of North America complemented their beans with squash.

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Figure 50.5 A Strategy for Vegetarians By combining cereal grains with legumes, an adult vegetarian can obtain all eight essential amino acids.

Human infants are thought to require four additional amino acids in their diets: histidine, tyrosine, cysteine, and arginine. Also, some amino acids are required by individuals with certain metabolic disorders who cannot synthesize them adequately. For example, individuals with the genetic disease phenylketonuria lack the enzyme for converting phenylalanine to tyrosine (see Key Concept 15.2) and must obtain tyrosine from their diets. They must keep their dietary intake of phenylalanine low to prevent its accumulation to toxic levels.

Why are dietary proteins completely digested to their constituent amino acids before being used by the body? Wouldn’t it be more energy-efficient to reuse some dietary proteins directly? There are several reasons why ingested proteins are not used “as is”:

Humans can synthesize almost all the lipids required by the body using acetyl groups obtained from food (see Figure 50.4), but we must have a dietary source of two essential fatty acids—linoleic acid and alpha-linolenic acid—that we cannot synthesize. Linoleic acid is needed by mammals to synthesize other unsaturated fatty acids, such as arachidonic acid, which is a component of several signaling molecules, including prostaglandins. Essential fatty acids are also necessary components of membrane phospholipids. A deficiency of linoleic acid can lead to problems such as infertility and impaired lactation, but because it is commonly present in vegetable oils, a deficiency is unlikely in an adequately nourished individual.