A B Cell Builds an Antibody

Question 1 of 4

Animation 41.3 Quiz

What is the sequence of the regions in the gene encoding the variable and constant regions of the light chain of an immunoglobulin molecule?

V, constant, D

J, constant, V

V, J, constant

Constant, V, J

Correct. See Key Concept 41.4 The Humoral Adaptive Response Involves Antibodies

Incorrect. See Key Concept 41.4 The Humoral Adaptive Response Involves Antibodies

Animation 41.3 Quiz

The DNA encodes many more segments than are actually used in a single antibody. At what stage are the intervening sequences not found in the final antibody molecule removed and discarded?

All are removed and discarded within the DNA prior to transcription.

All are removed and discarded during splicing of mRNA transcripts.

All are removed and discarded from the protein after translation.

Some are removed and discarded within the DNA prior to transcription and the rest are removed and discarded during splicing of mRNA transcripts.

Correct. See Key Concept 41.4 The Humoral Adaptive Response Involves Antibodies

Incorrect. See Key Concept 41.4 The Humoral Adaptive Response Involves Antibodies

Animation 41.3 Quiz

How would the DNA of a skin cell compare with the DNA of a mature plasma B cell taken from the same individual?

They would be identical.

There would be more DNA in the skin cell than in the mature plasma B cell, and all of the B cell DNA would be represented within skin cell DNA.

There would be more DNA in the mature plasma B cell than in the skin cell, and all of the skin cell DNA would be represented within B cell DNA.

There would be an equal amount of DNA in the skin cell and in the mature plasma B cell, but it would not all be identical.

Correct. See Key Concept 41.4 The Humoral Adaptive Response Involves Antibodies

Incorrect. See Key Concept 41.4 The Humoral Adaptive Response Involves Antibodies

Animation 41.3 Quiz

Refer to the figure below.

In this simplified illustration of the DNA region coding for heavy chain antibody fragments, there are four V segments (yellow), five D segments (purple), four J segments (pink), and one constant segment (green). Assume that this represents the total number of different segments in a heavy chain gene. (In humans and mice, there are actually more of each type). How many different heavy chain variable regions could be created if the V, D, and J segments can randomly rearrange? Recall that the variable regions are coded for by one of each type of segment.

140

8 million

Correct. See Key Concept 41.4 The Humoral Adaptive Response Involves Antibodies

Incorrect. See Key Concept 41.4 The Humoral Adaptive Response Involves Antibodies

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Chapter 1. A B Cell Builds an Antibody