EXPERIMENTAL FIGURE 10-30 THE FUNCTION OF MIRNAS IN LIMB DEVELOPMENT. Micrographs comparing normal (left) and Dicer-knockout (right) limbs of 13-day mouse embryos immunostained for the Gd5 protein, a marker of joint formation. Dicer is knocked out in the limbs of developing mouse embryos by conditional expression of Cre to induce deletion of the dicer gene in only those cells (see Figure 6-40).

[From Harfe, B.D., et al., “The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb,” Proc. Natl. Acad. Sci. USA, 2005, 102(31):10898–903. Copyright (2005) National Academy of Sciences, USA.]