FIGURE 18-26 The dynactin complex links dynein to cargo. (a) One domain of the complex, which binds cargo, is built around a short filament made up of eight subunits of the actin-related protein Arp1 and one actin subunit, capped by CapZ. Another domain consists of the protein p150^Glued, which has a microtubule-binding site on its distal end and is also involved in attaching cytoplasmic dynein to the complex. Dynamitin holds the two parts of the dynactin complex together. (b) Diagram of how the dynactin and dynein complex interact with each other and with a microtubule. See Urnavicius et al. 2015, Science 347:1441.