EXPERIMENTAL FIGURE 18-27 The LIS1 protein, which regulates dynein, is required for brain development. (a) Model of how NudE associates with dynein to allow LIS1 to interact with the ATPase domain of the dynein heavy chain. See McKenny et al., 2010, Cell 141:304–314. (b) Magnetic resonance images (MRIs) of a normal brain (left) and a brain from a patient with Miller-Dieker lissencephaly (right), which results from a lack of LIS1 function. Notice the absence of folding in the patient’s brain at the locations marked by the arrows.

[Part (b) from Kato, M. & Dobyns, W. B. “Lissencephaly and the molecular basis of neuronal migration,” Hum. Mol. Genet. (2003) 12, R89-R96, by permission of Oxford University Press.]