FIGURE 18-51 The nuclear lamina is attached to chromatin and through LINC complexes to the cytoskeleton. (a) Diagram of part of a nucleus, showing the association of the lamin-containing nuclear lamina with chromatin and, through the two membranes of the nucleus, with the cytoskeleton. Proteins such as the membrane-associated lamin B receptor and emerin tether the lamin intermediate filaments to the inner nuclear membrane. Lamins are also tethered to the nuclear membrane by the prenylation of lamin B (not shown). Diverse linkages, called LINC complexes, attach the lamins through the two nuclear membranes to the cytoskeleton. (b) A LINC complex consists of a SUN domain–containing protein that interacts with lamins and extends across the inner nuclear membrane, and a KASH domain–containing protein that interacts with a SUN domain–containing protein in the perinuclear space and crosses the outer nuclear membrane to interact with components of the cytoskeleton. See B. Burke and C. L. Stewart, 2013, Nat. Rev. Mol. Cell Biol. 14:13.