FIGURE 19-26 The protein phosphatase Cdc14 triggers exit from mitosis in budding yeast. During mitosis, mitotic CDK activity inhibits its inhibitors, APC/C^Cdh1 and Sic1. During G₁, APC/C^Cdh1 and Sic1 inhibit mitotic CDKs. During exit from mitosis, the protein phosphatase Cdc14 throws the switch between these two antagonistic states. The mitotic exit network activates the phosphatase during anaphase, allowing it to dephosphorylate APC/C^Cdh1, thereby activating it. The phosphatase also promotes the accumulation of Sic1. In addition, Cdc14 dephosphorylates the many mitotic CDK substrates, which leads to rapid exit from mitosis.