EXPERIMENTAL FIGURE 21-26 Par proteins are asymmetrically localized in the one-cell worm embryo. (a) DIC images of wild-type and par3 mutant embryos. Notice that in wild-type cells, the AB cell is larger than the P1 cell, whereas they are the same size in the par3 mutant. The par3 mutant also has a defect in spindle orientation (as seen by microtubule staining in green) and P-granule (red) segregation. DNA is stained blue. (b) Complementary localization of the anterior Par complex (Cdc42-Par3-Par6-aPKC) (red) and posterior determinants (green) in the one-cell embryo.

[Parts (a) and (b) courtesy of Diane Morton and Kenneth Kemphues.]