CLASSIC EXPERIMENT FIGURE 2 Schematic diagram of κ light-chain DNA in embryonic cells and B cells that is consistent with Tonegawa’s results. In embryonic cells, cleavage with the BamHI restriction enzyme (red arrows) produces two different-sized fragments, one containing the V gene and one containing the C gene. In B cells, the DNA is rearranged so that the V and C genes are adjacent, with no intervening cleavage site. BamHI digestion thus yields one fragment that contains both the V and C genes.