EXPERIMENTAL FIGURE 24-10 The incidence of human cancers increases as a function of age. The marked increase in the incidence of cancer with age is consistent with the multi-hit model of cancer induction. Note that the logarithm of annual incidence is plotted versus the logarithm of age.

[Data from B. Vogelstein and K. Kinzler, 1993, Trends Genet. 9:138–141.]