FIGURE 5-42 Alternative resolution of a Holliday structure. Diagonal and vertical lines represent a single phosphodiester bond. It is simplest to diagram the process by rotating the diagram of the bottom molecule 180° so that the top and bottom molecules have the same strand orientations. Cutting the bonds as shown in 1 and ligating the ends as indicated regenerates the original chromosomes. Cutting the strands as shown in 2 and religating as shown at the bottom generates recombinant chromosomes