FIGURE 7-23 Solubilization of integral membrane proteins by non-ionic detergents. At a concentration higher than its critical micelle concentration (CMC), a detergent solubilizes lipids and integral membrane proteins, forming mixed micelles containing detergent, protein, and lipid molecules. At concentrations below the CMC, non-ionic detergents (e.g., octylglucoside, Triton X-100) can dissolve membrane proteins without forming micelles by coating the membrane-spanning regions.