FIGURE 8-42 Kinetochore-microtubule interaction in S. cerevisiae. (a) Sequence of the simple centromeres of S. cerevisiae. See L. Clarke and J. Carbon, 1985, Ann. Rev. Genet. 19:29. (b) Ndc80 complexes associate with both the microtubule and the CBF3 complex. (c) Diagram of the centromere-associated CBF3 complex and its associated Ndc80 complexes, which associate with a ring of Dam1 proteins at the end of a spindle microtubule. The Ndc80 complexes initially make lateral interactions with the side of a spindle microtubule (top) and then associate with the Dam1 ring, making an end-on attachment (bottom) to the microtubule. See T. U. Tanaka, 2010, EMBO J. 29:4070.