In updating, revising, and rewriting this book, we were given invaluable help by many colleagues. We thank the following people who generously gave of their time and expertise by making contributions to specific chapters in their areas of interest, providing us with detailed information about their courses, or by reading and commenting on one or more chapters:
David Agard, University of California, San Francisco, and Howard Hughes Medical Institute
Ann Aguanno, Marymount Manhattan College
Stephen Amato, Northeastern University
Shivanthi Anandan, Drexel University
Kenneth Balazovich, University of Michigan
Amit Banerjee, Wayne State University
Lisa Banner, California State University, Northridge
Benjamin Barad, University of California, San Francisco
Kenneth Belanger, Colgate University
Andrew Bendall, University of Guelph
Eric Betzig, Howard Hughes Medical Institute
Subhrajit Bhattacharya, Auburn University
Ashok Bidwai, West Virginia University
David Bilder, University of California, Berkeley
Elizabeth Blinstrup-
Jenna Bloemer, Auburn University
Jonathan Bogan, Yale University School of Medicine
Indrani Bose, Western Carolina University
Laurie Boyer, Massachusetts Institute of Technology
James Bradley, Auburn University
Eric Brenner, New York University
Mirjana Brockett, Georgia Institute of Technology
Manal Buabeid, Auburn University
Heike Bucking, South Dakota State University
Tim Burnett, Emporia State University
Samantha Butler, University of California, Los Angeles
W. Malcolm Byrnes, Howard University College of Medicine
Monique Cadrin, University of Quebec Trois-
Martin Cann, Durham University
Steven A. Carr, Broad Institute of Massachusetts Institute of Technology and Harvard
Suzie Chen, Rutgers University
Cindy Cooper, Truman State University
David Daleke, Indiana University
Thomas J. Deerinck, University of California, San Diego
Linda DeVeaux, South Dakota School of Mines and Technology
David Donze, Louisiana State University
William Dowhan, University of Texas, Houston
Janet Duerr, Ohio University
Manoj Duraisingh, Harvard School of Public Health
Paul Durham, Missouri State University
David Eisenberg, University of California, Los Angeles
Sevinc Ercan, New York University
Marilyn Farquhar, University of California, San Diego
Jeffrey Fillingham, Ryerson University
Kathleen Fitzpatrick, Simon Fraser University
Friedrich Foerster, Max Planck Institute of Biochemistry
Margaret T. Fuller, Stanford University School of Medicine
Warren Gallin, University of Alberta
Liang Gao, Stony Brook University
Chris Garcia, Stanford University School of Medicine
Mary Gehring, Massachusetts Institute of Technology
Jayant Ghiara, University of California, San Diego
David Gilmour, Pennsylvania State University
Alfred Goldberg, Harvard Medical School
Sara Gremillion, Armstrong State University
Lawrence I. Grossman, Wayne State University
Barry M. Gumbiner, University of Washington and Seattle Children’s Research Institute
Yanlin Guo, University of Southern Mississippi
Gyorgy Hajnoczky, Thomas Jefferson University
Nicholas Harden, Simon Fraser University
Maureen Harrington, Indiana University
Michael Harrington, University of Alberta
Marcia Harrison-
Craig Hart, Louisiana State University
Andreas Herrlich, Harvard Medical School
Ricky Hirschhorn, Hood College
Barry Honda, Simon Fraser University
H. Robert Horvitz, Massachusetts Institute of Technology
Nai-
Richard O. Hynes, Massachusetts Institute of Technology and Howard Hughes Medical Institute
Rudolf Jaenisch, Massachusetts Institute of Technology
Cheryl Jorcyk, Boise State University
Naohiro Kato, Louisiana State University
Amy E. Keating, Massachusetts Institute of Technology
Younghoon Kee, University of South Florida
Eirini Kefalogianni, Harvard Medical School
Thomas Keller, Florida State University
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Greg Kelly, University of Western Ontario
Baljit Khakh, University of California, Los Angeles
Lou Kim, Florida International University
Thomas Kirchhausen, Harvard Medical School
Elaine Kirschke, University of California, San Francisco
Cindy Klevickis, James Madison University
Donna Koslowsky, Michigan State University
Diego Krapf, Colorado State University
Arnold Kriegsten, University of California, San Francisco
Michael LaGier, Grand View University
Brett Larson, Armstrong Atlantic State University
Mark Lazzaro, College of Charleston
Daniel Leahy, Johns Hopkins University School of Medicine
Wesley Legant, Howard Hughes Medical Institute
Fang Ju Lin, Coastal Carolina University
Susan Lindquist, Massachusetts Institute of Techology
Adam Linstedt, Carnegie Mellon University
Jennifer Lippincott-
James Lissemore, John Carroll University
Richard Londraville, University of Akron
Elizabeth Lord, University of California, Riverside
Charles Mallery, University of Miami
George M. Martin, University of Washington
Michael Martin, John Carroll University
C. William McCurdy, University of California, Davis, and Lawrence Berkeley National Laboratory
James McNew, Rice University
Ivona Mladenovic, Simon Fraser University
Vamsi K. Mootha, Harvard Medical School and Massachusetts General Hospital
Tsafrir Mor, Arizona State University
Roderick Morgan, Grand Valley State University
Sean Morrison, University of Texas Southwestern Medical School
Aris Moustakas, Ludwig Institute, Uppsala University, Sweden
Dana Newton, College of The Albemarle
Bennett Novitch, University of California, Los Angeles
Roel Nusse, Stanford University School of Medicine
Jennifer Panizzi, Auburn University
Samantha Parks, Georgia State University
Ardem Patapoutian, The Scripps Research Institute
Rekha Patel, University of South Carolina
Aaron Pierce, Nicholls State University
Joel Piperberg, Millersville University of Pennsylvania
Todd Primm, Sam Houston State University
April Pyle, University of California, Los Angeles
Nicholas Quintyne, State University of New York at Fredonia
Peter Reddien, Massachusetts Institute of Technology
Mark Reedy, Creighton University
Dan Reines, Emory University
Jatin Roper, Tufts University School of Medicine
Evan Rosen, Harvard Medical School
Richard Roy, McGill University
Edmund Rucker, University of Kentucky
Helen Saibil, University of London
Alapakkam Sampath, University of California, Los Angeles
Peter Santi, University of Minnesota
Burkhard Schulz, Purdue University
Thomas Schwartz, Massachusetts Institute of Technology
Stylianos Scordilis, Smith College
Kavita Shah, Purdue University
Lin Shao, Howard Hughes Medical Institute
Allan Showalter, Ohio University
Jeff Singer, Portland State University
Agnes Southgate, College of Charleston
Daniel Starr, University of California, Davis
Jacqueline Stephens, Louisiana State University
Emina Stojkovic, Northeastern Illinois University
Paul Teesdale-
Kurt Toenjes, Montana State University Billings
Fredrik Vannberg, Georgia Institute of Technology
Pavithra Vivekanand, Susquehanna University
Claire Walczak, Indiana University
Barbara Waldman, University of South Carolina
Feng-
Irving Wang, Whitehead Institute for Biomedical Research
Keith Weninger, North Carolina State University
Laurence Wong, Canadian University College
Ernest Wright, University of California, Los Angeles
Michael B. Yaffe, Massachusetts Institute of Technology
Ning Yan, Tshinghua University
Omer Yilmaz, Massachusetts Institute of Technology
Junying Yuan, Harvard Medical School
Ana Zimmerman, College of Charleston
We would also like to express our gratitude and appreciation to all those who contributed to the resources on LaunchPad. A full list of these contributors is posted on the Molecular Cell Biology, Eighth Edition, LaunchPad.
This edition would not have been possible without the careful and committed collaboration of our publishing partners at W. H. Freeman and Company. We thank Kate Ahr Parker, Beth Cole, Will Moore, Liz Geller, Norma Sims Roche, Blake Logan, Janice Donnola, Jennifer MacMillan, Sheena Goldstein, Teri Stratford, Nandini Ahuja, Abigail Fagan, Felicia Ruocco, Hilary Newman, Amy Thorne, Kathleen Wisneski, and Paul Rohloff for their labor and for their willingness to work overtime to produce a book that excels in every way.
In particular, we would like to acknowledge the talent and commitment of our text editors, Erica Champion and Heather Moffat. They are remarkable editors. Thank you for all you’ve done in this edition.
Page xviii
We are also indebted to H. Adam Steinberg for his pedagogical insight and his development of beautiful molecular models and illustrations.
We would like to acknowledge those whose direct contributions to previous editions continue to influence in this edition, especially Ruth Steyn.
Thanks to our own staff: Sally Bittancourt, Diane Bush, Mary Anne Donovan, Carol Eng, James Evans, George Kokkinogenis, Julie Knight, Guicky Waller, Nicki Watson, and Rob Welsh.
Finally, special thanks to our families for inspiring us and for granting us the time it takes to work on such a book and to our mentors and advisers for encouraging us in our studies and teaching us much of what we know: (Harvey Lodish) my wife, Pamela; my children and grandchildren Heidi and Eric Steinert and Emma and Andrew Steinert; Martin Lodish, Kristin Schardt, and Sophia, Joshua, and Tobias Lodish; and Stephanie Lodish, Bruce Peabody, and Isaac and Violet Peabody; mentors Norton Zinder and Sydney Brenner; and also David Baltimore and Jim Darnell for collaborating on the first editions of this book; (Arnold Berk) my wife Sally, Jerry Berk, Shirley Berk, Angelina Smith, David Clayton, and Phil Sharp; (Chris A. Kaiser) my wife Kathy O’Neill, my mentors David Botstein and Randy Schekman; (Monty Krieger) my wife Nancy Krieger, parents I. Jay Krieger and Mildred Krieger, children Joshua and Ilana Krieger and Jonathan Krieger and Sofia Colucci, and grandchild Joaquin Krieger; my mentors Robert Stroud, Michael Brown, and Joseph Goldstein; (Anthony Bretscher) my wife Janice and daughters Heidi and Erika, and advisers A. Dale Kaiser and Klaus Weber; (Hidde Ploegh) my wife Anne Mahon; (Angelika Amon) my husband Johannes Weis, Theresa and Clara Weis, Gerry Fink and Frank Solomon; (Kelsey C. Martin) my husband Joel Braslow, children Seth, Ben, Sam, and Maya, father George M. Martin, and mentors Ari Helenius and Eric Kandel.